Neurogenesis (with Carlotta Barelli)

In this episode, we were joined by a special guest, Carlotta Barelli, to discuss the controversy surrounding adult neurogenesis. Are new neurons generated throughout life in humans and, if so, what are the implications?

What is neurogenesis?

Adult neurogenesis and functional plasticity in neuronal circuits (Lledo et al., 2006) https://www.nature.com/articles/nrn1867

Does neurogenesis occur in adult humans?

Neurogenesis in the adult human hippocampus (Eriksson et al., 1998) doi: 10.1038/3305.

Dynamics of hippocampal neurogenesis in adult humans (Spalding et al., 2013) doi: 10.1016/j.cell.2013.05.002.

Human Adult Neurogenesis: Evidence and Remaining Questions (Kempermann et al., 2018) doi: 10.1016/j.stem.2018.04.004.

What is the purpose of adult neurogenesis?

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (Deng et al., 2010) doi: 10.1016/j.stem.2018.04.004.

What activities stimulate or alter neurogenesis?

Exercise plasma boosts memory and dampens brain inflammation via clusterin (De Miguel et al., 2021) https://doi.org/10.1038/s41586-021-04183-x

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus (Pereira et al., 2007) https://doi.org/10.1073/pnas.0611721104

Regulation of adult neurogenesis and plasticity by (Early) stress, glucocorticoids, and inflammation (Lucassen et al., 2015) https://doi.org/10.1101/cshperspect.a021303

Regulation and function of adult neurogenesis: from genes to cognition (Aimone et al., 2014) doi: 10.1152/physrev.00004.2014.

Comparing neurogenesis across animals…how is neurogenesis intertwined with evolution?

What is the relationship between hippocampal neurogenesis across different stages of the lifespan? (Bond et al., 2022) https://www.frontiersin.org/articles/10.3389/fnins.2022.891713/full

New neurons for ‘survival of the fittest’ (Kempermann, 2012) https://www.nature.com/articles/nrn3319

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